P-213: Comparison of Controlled Ovarian Stimulation with Clomiphen Citrate+ HMG or Clomiphen Citrate+ rFSH in IUI Cycles

Background: Different protocols are used for controlled ovarian hyper stimulation (COH), but the optimal method has not yet been determined. So we decided to compare the outcome of controlled ovarian stimulation using clomiphen citrate +HMG versus clomiphen citrate +rFSH in IUI cycles. Materials and Methods: 144 women with unexplained or male factor infertility undergoing IUI cycles (72 patients in CC+ rFSH group and 72 patients in CC+ HMG group) were randomized and included in this single blind study. The study was performed in Amir-Al-Momenin university hospital from October 2006 to June 2010.The primary outcomes were clinical and ongoing pregnancy rates. The number of dominant follicles, mean of follicular size, endometrial thickness on the day of HCG administration, total dose of gonadotropins and duration of stimulation with gonadotropins were secondary outcomes. Results: Clinical and ongoing pregnancy rates were not significantly different from each other in the two groups (11.1%, 9.7% in CC + HMG group and 12.5%, 12.5% in CC + rFSH group, respectively; p>0.05).There were no statistically significant differences in secondary outcome measures between the two groups. Conclusion: Considering the similar pregnancy rate, the similar total dose and duration of stimulation with gonadotropins in both groups and the higher cost per ampoule in CC + rFSH group versus CC + HMG group, it seems that CC + HMG is a more suitable and cost-effective regimen than CC + rFSH in IUI cycles in patients with unexplained or male factor infertility.0ur sample size was small.So further larger studies are necessary to confirm our results.